Cystic Fibrosis (CF), an inherited multi‐system disease, is caused by mutations in the Cystic
Fibrosis Transmembrane Conductance Regulator (CFTR) that disrupt its ability to secrete …

Inhaled corticosteroids (ICSs) are used as first‐line drugs for asthma, and various novel
antiasthma drugs targeting type 2 immune mediators are now under development. However …

Dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) anion
channel by genetic mutations causes the inherited disease cystic fibrosis (CF). CF lung …

Abstract Background/Aims: Pendrin is a Cl-/I-/HCO3-exchanger playing a fundamental role
in controlling blood pressure and airway function, therefore representing an attractive target …

Bicarbonate transporters are responsible for the appropriate flux of bicarbonate across the
plasma membrane to perform various fundamental cellular functions. The functions of …

Objective: The aim of this study is to evaluate the role of pendrin in acute lung injury
(ALI)/acute respiratory distress syndrome (ARDS) and to explore whether pendrin …

Pendrin (SLC26A4), a Cl−/anion exchanger, is expressed at high levels in kidney, thyroid,
and inner ear epithelia, where it has an essential role in bicarbonate secretion/chloride …

Cystic fibrosis (CF) is the most common life-threatening inherited disorder affecting
Caucasians. It is caused by mutations in the CFTR gene that generate impaired cystic …

Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport
mechanisms in the airways are not well understood. cAMP stimulates anion efflux through …

The airway epithelium plays a protective role against microbial pathogens delivered by
inhaled air. We used cultured bronchial epithelia, differentiated in vitro under air-liquid …