The role of lipid components in lipid nanoparticles for vaccines and gene therapy
CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
Chemistry of lipid nanoparticles for RNA delivery
Conspectus Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery
In 2021, mRNA vaccines against COVID-19 were approved by the Food and Drug
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …
Characterization of nanoparticles-based vaccines for COVID-19
Several vaccines against COVID-19 use nanoparticles to protect the antigen cargo (either
proteins or nucleic acids), increase the immunogenicity and ultimately the efficacy. The …
proteins or nucleic acids), increase the immunogenicity and ultimately the efficacy. The …
Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Several studies have utilized a lipid nanoparticle delivery system to enhance the
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine
Lipid nanoparticle (LNP)-formulated nucleoside-modified mRNA vaccines have proven to be
very successful in the fight against the coronavirus disease 2019 (COVID-19) pandemic …
very successful in the fight against the coronavirus disease 2019 (COVID-19) pandemic …
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …
diseases and genetic disorders by regulating disease-related gene expression. The …
Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects
In the last decade, the development of messenger RNA (mRNA) therapeutics by lipid
nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of …
nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of …
[HTML][HTML] Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging
Lipid nanoparticles (LNPs) have been one of the most successful nano-delivery vehicles
that enable efficient delivery of cytotoxic chemotherapy agents, antibiotics, and nucleic acid …
that enable efficient delivery of cytotoxic chemotherapy agents, antibiotics, and nucleic acid …
Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity
Lipid nanoparticles (LNPs) can be designed to potentiate cancer immunotherapy by
promoting their uptake by antigen-presenting cells, stimulating the maturation of these cells …
promoting their uptake by antigen-presenting cells, stimulating the maturation of these cells …