Highlights•Focus on disease-modifying approaches for intra-articular drug
delivery.•Polymeric particles as platforms for sustained and controlled drug release.•In vivo …

Osteoarthritis is a progressive and heterogeneous joint disease with complex pathogenesis.
The various phenotypes associated with each patient suggest that better subgrouping of …

Background Osteoarthritis (OA), which is due to the progressive loss and degeneration of
articular cartilage, is the leading cause of disability worldwide. Therefore, it is of great …

Knee osteoarthritis (KOA) is a major cause of leg disability in the elderly population.
Recently, the expression levels of circulating microRNA (miRNA) let-7e have been reported …

Background. Immunological mechanisms play a vital role in the pathogenesis of knee
osteoarthritis (KOA). Moreover, the immune phenotype is a relevant prognostic factor in …

GEO数据库联合机器学习策略识别骨关节炎特征性lncRNA分子标志物及实验验证- PMC Back to
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Objective Osteoarthritis (OA) is a complex disease involving contributions from both local
joint tissues and systemic sources. Patient characteristics, encompassing sociodemographic …

Background: Osteoarthritis (OA) is one of the main causes of disability in the elderly
population, accompanied by a series of underlying pathologic changes, such as cartilage …

Meniscus plays an important role in joint homeostasis. Tear or degeneration of meniscus
might facilitate the process of knee osteoarthritis (OA). Hence, to investigate the …

Objective Recent evidence delineates an emerging role of periostin in osteoarthritis (OA),
since its expression after knee injury is detrimental to the articular cartilage. We undertook …