Adenosine and brain function

BB Fredholm, JF Chen, RA Cunha… - Int Rev …, 2005 - books.google.com
A. Cellular and Subcellular Localization B. Pharmacological Tools to Study Adenosine
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …

[HTML][HTML] The role of altered BDNF/TrkB signaling in amyotrophic lateral sclerosis

J Pradhan, PG Noakes, MC Bellingham - Frontiers in cellular …, 2019 - frontiersin.org
Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions,
via activation of its high affinity receptor, tropomysin related kinase B (TrkB). In addition …

Activation of Trk neurotrophin receptors in the absence of neurotrophins

FS Lee, MV Chao - Proceedings of the National Academy of …, 2001 - National Acad Sciences
Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk
receptor tyrosine kinases. Binding of neurotrophins to Trk receptors results in receptor …

Ophidian envenomation strategies and the role of purines

SD Aird - Toxicon, 2002 - Elsevier
Snake envenomation employs three well integrated strategies: prey immobilization via
hypotension, prey immobilization via paralysis, and prey digestion. Purines (adenosine …

Modulation of three key innate immune pathways for the most common retinal degenerative diseases

I Akhtar‐Schäfer, L Wang, TU Krohne, H Xu… - EMBO molecular …, 2018 - embopress.org
This review highlights the role of three key immune pathways in the pathophysiology of
major retinal degenerative diseases including diabetic retinopathy, age‐related macular …

Adenosine receptors and neurological disease: neuroprotection and neurodegeneration

TW Stone, S Ceruti, MP Abbracchio - Adenosine receptors in health and …, 2009 - Springer
Adenosine receptors modulate neuronal and synaptic function in a range of ways that may
make them relevant to the occurrence, development and treatment of brain ischemic …

Adenosine receptor–dopamine receptor interactions in the basal ganglia and their relevance for brain function

K Fuxe, S Ferré, S Genedani, R Franco, LF Agnati - Physiology & behavior, 2007 - Elsevier
The dopamine D1 and D2 receptors are major receptors in the regulation of striatal function
and striatal adenosine A1 and A2A receptors are major modulators of their signaling. The …

Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum

BD Hettinger, A Lee, J Linden… - Journal of Comparative …, 2001 - Wiley Online Library
Activation of adenosine A2A receptors (A2AR) has been shown to antagonize the function of
D2 dopaminergic regulation of striatal γ‐aminobutyric acid (GABA)‐ergic output and, thus …

Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders

RA Cunha, S Ferré, JM Vaugeois… - Current pharmaceutical …, 2008 - ingentaconnect.com
The interest on targeting adenosine A2A receptors in the realm of psychiatric diseases first
arose based on their tight physical and functional interaction with dopamine D2 receptors …

Anatomy of adenosine A2A receptors in brain: Morphological substrates for integration of striatal function

DL Rosin, BD Hettinger, A Lee, J Linden - Neurology, 2003 - AAN Enterprises
A2A adenosine receptors (A2ARs) are expressed with the greatest abundance in the
striatum and other nuclei of the basal ganglia. The segregated expression of A2ARs on the …