The striatum is a subcortical area involved in sensorimotor, cognitive and emotional
processes. Adenosine A2A receptors (A2ARs) are highly expressed in the striatum, and their …

The synthesis of a 25 000 member library of nucleoside analogues as discrete compounds
in milligram quantities is described. The use of the Nanokan technology developed by IRORI …

Despite newly developed antiepileptic drugs to suppress epileptic symptoms, approximately
one third of patients remain drug refractory. Consequently, there is an urgent need to …

Adenosine is present in all cells and is implicated in the control of the function of every tissue
and organ. The elevated adenosine levels seem to play a significant role in a protection …

Antrodia cinnamomea (formerly named Antrodia camphorata) is a rare medicinal fungus. We
previously reported that it exhibits antioxidative, vasorelaxative, anti-inflammatory, and anti …

Adenosine is an endogenous purine nucleoside that plays a neuromodulatory role in the
central nervous system. A2a adenosine receptors have been involved in reward-related …

Abstract Prostaglandin D 2 (PGD 2) is one of the most potent endogenous sleep promoting
substances. PGD 2 activates the PGD 2 receptor (DPR) and increases the extracellular level …

The present study investigated 1) antihyperalgesic actions of a novel and selective
adenosine kinase (AK) inhibitor, A-134974 (IC50= 60 pM), in the carrageenan model of …

Cerebral ischemia studies demonstrating that stimulation of adenosine A1 receptors by
either endogenously released adenosine or the administration of selective receptor agonists …

Cytochrome P450 monooxygenases or CYPs, a family of endobiotics and xenobiotics
metabolizing enzymes, are found in all organisms. We reported earlier that the promoters of …