Cytokines are critical in regulating immune responses and cellular behavior, playing dual
roles in both normal physiology and the pathology of diseases such as cancer. These …

Natural Killer (NK) cells are a top contender in the development of adoptive cell therapies for
cancer due to their diverse antitumor functions and ability to restrict their activation against …

Immunogenic cell death (ICD) is a stress-driven form of regulated cell death (RCD) in which
dying tumor cells' specific signaling pathways are activated to release damage-associated …

The activation of innate immunity and associated interferon (IFN) signaling have been
implicated in cancer, but the regulators are elusive and a link to tumor suppression …

Type I interferons have been well recognized for their roles in various types of immune cells
during tumor immunotherapy. However, their direct effects on tumor cells are less …

The present volume of Immunological Reviews deals with the mechanisms of programmed
cell death, obviously from an immunological perspective. What are the consequences of cell …

Although a lot of effort has been put into creating drugs and combination therapies against
chronic hepatitis, no effective treatment has been established. Type-I interferon is a …

Rationale: Surgical resection is a primary treatment for solid tumors, but high rates of tumor
recurrence and metastasis post-surgery present significant challenges. Manganese (Mn 2+) …

Recently, various cancer types have been identified to express a distinct subset of Interferon-
stimulated genes (ISGs) that mediate therapy resistance. The mechanism through which …

Introduction Cancer-associated fibroblasts (CAFs) are abundant and influential elements of
the tumor microenvironment (TME), giving support to tumor development in multiple ways …