Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which
maintain lung homeostasis through their dual roles as anti-infectious and …

Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …

Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and
secreted into the airspaces, where it coats and protects the large respiratory air–liquid …

Pulmonary surfactant has two crucial roles in respiratory function; first, as a biophysical entity
it reduces surface tension at the air water interface, facilitating gas exchange and alveolar …

Danger‐associated molecular patterns (DAMPs) are host‐derived molecules that can
function to regulate the activation of pathogen recognition receptors (PRRs). These …

Lipopolysaccharide (LPS), a key component of the outer membrane in Gram-negative
bacteria (GNB), is widely recognized for its crucial role in mammalian innate immunity and …

Pneumonia remains the leading cause of death from infection in the US, yet fundamentally
new conceptual models underlying its pathogenesis have not emerged. We show that …

Ubiquitin is a post-translational protein modifier and plays essential roles in all aspects of
biology. Although the discovery of ubiquitin introduced this highly conserved protein as a …

Lipopolysaccharide (LPS) induces host inflammatory responses and tissue injury and has
been implicated in the pathogenesis of various age-related diseases such as acute …

The alveolar epithelium serves as a barrier between organism and environment and
functions as the first line of protection against potential respiratory pathogens. Alveolar type …