The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …

The dorsal medial prefrontal cortex (dmPFC) has been recognized as a key cortical area for
nociceptive modulation. However, the underlying neural pathway and the function of specific …

Pain is an integrated sensory and affective experience. Cortical mechanisms of sensory and
affective integration, however, remain poorly defined. Here, we investigate the projection …

Neurons in the prefrontal cortex (PFC) can provide top-down regulation of sensory-affective
experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however …

Effective treatments for chronic pain remain limited. Conceptually, a closed-loop neural
interface combining sensory signal detection with therapeutic delivery could produce timely …

Chronic pain is characterized by discrete pain episodes of unpredictable frequency and
duration. This hinders the study of pain mechanisms and contributes to the use of …

Background/Objective: Non-invasive neuromodulation techniques, such as repetitive
Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation …

Acute pain evokes protective neural and behavioral responses. Chronic pain, however,
disrupts normal nociceptive processing. The prefrontal cortex (PFC) is known to exert top …

Pain is a complex perceptual phenomenon. Coordinated activity among local and distant
brain networks is a central element of the neural underpinnings of pain. Brain oscillatory …