Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease characterized by
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …

Tissue engineering scaffolds have emerged as a powerful tool within regenerative medicine.
These materials are being designed to create environments that promote regeneration …

Aberrant T-cell activation underlies many autoimmune disorders, yet most attempts to induce
T-cell tolerance have failed. Building on previous strategies for tolerance induction that …

Multiple sclerosis (MS) is a devastating inflammatory disease of the brain and spinal cord
that is thought to result from an autoimmune attack directed against antigens in the central …

Background & Aims Celiac disease could be treated, and potentially cured, by restoring T-
cell tolerance to gliadin. We investigated the safety and efficacy of negatively charged 500 …

As the science of immunology grows increasingly mechanistic, motivation for developing
quantitative, design-based engineering approaches has also evolved, both for therapeutic …

Ag-specific tolerance is a highly desired therapy for immune-mediated diseases.
Intravenous infusion of protein/peptide Ags linked to syngeneic splenic leukocytes with …

Strategies to enhance, suppress, or qualitatively shape the immune response are of
importance for diverse biomedical applications, such as the development of new vaccines …

Regulatory T cells (Tregs) are long-lived cells that suppress immune responses in vivo in a
dominant and antigen-specific manner. Therefore, therapeutic application of Tregs to control …

Autoimmune disease is a chronic inflammatory disease caused by disorders of immune
regulation. Antigen-specific immunotherapy has the potential to inhibit the autoreactivity of …