Sustaining and maintaining the intricate process of spermatogenesis is liable upon
hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli …

The Sertoli cell, which is the supporting cell of spermatogenesis, has an important role in the
endocrine and paracrine control of spermatogenesis. Functionally, it provides the cells of the …

Caffeine is a widely consumed substance present in several beverages. There is an
increasing consumption of energetic drinks, rich in caffeine, among young individuals in …

Oxidative stress is a well-established event in the pathology of several neurobiological
diseases. Sirt3 is a nicotinamide adenine nucleotide (NAD+)-dependent protein deacetylase …

Spermatogenesis is contingent upon hormones and growth factors acting through endocrine
and paracrine pathways either in vivo or in vitro. Sertoli cells (SCs) furnish essential factors …

Diabetes mellitus (DM) is one of the most prevalent chronic diseases and has been a
leading cause of death in the last decades. Thus, methods to detect, prevent or delay this …

The incidence of type 2 diabetes mellitus and its prodromal stage, pre-diabetes, is rapidly
increasing among young men, leading to disturbances in testosterone synthesis. However …

Melatonin co-operates with insulin in the regulation of glucose homeostasis. Within the
testis, glucose metabolism in the somatic Sertoli cells (SCs) is pivotal for spermatogenesis …

Atorvastatin (ATV) generally used to treat dyslipidemia is also reported to have effect against
6-hydroxydopamine (6-OHDA) induced neurotoxicity. Additionally, atorvastatin can interfere …

Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic
phenotype and is involved in virtually all aspects of cellular function. It integrates not only …