Visual processing in the fly, from photoreceptors to behavior

TA Currier, MM Pang, TR Clandinin - Genetics, 2023 - academic.oup.com
Originally a genetic model organism, the experimental use of Drosophila melanogaster has
grown to include quantitative behavioral analyses, sophisticated perturbations of neuronal …

Visual circuits for direction selectivity

AS Mauss, A Vlasits, A Borst… - Annual review of …, 2017 - annualreviews.org
Images projected onto the retina of an animal eye are rarely still. Instead, they usually
contain motion signals originating either from moving objects or from retinal slip caused by …

[HTML][HTML] A single-cell transcriptome atlas of the aging Drosophila brain

K Davie, J Janssens, D Koldere, M De Waegeneer… - Cell, 2018 - cell.com
The diversity of cell types and regulatory states in the brain, and how these change during
aging, remains largely unknown. We present a single-cell transcriptome atlas of the entire …

Neuronal diversity and convergence in a visual system developmental atlas

MN Özel, F Simon, S Jafari, I Holguera, YC Chen… - Nature, 2021 - nature.com
Deciphering how neuronal diversity is established and maintained requires a detailed
knowledge of neuronal gene expression throughout development. In contrast to mammalian …

Optimized tools for multicolor stochastic labeling reveal diverse stereotyped cell arrangements in the fly visual system

A Nern, BD Pfeiffer, GM Rubin - Proceedings of the …, 2015 - National Acad Sciences
We describe the development and application of methods for high-throughput
neuroanatomy in Drosophila using light microscopy. These tools enable efficient multicolor …

[HTML][HTML] Super-resolution mapping of neuronal circuitry with an index-optimized clearing agent

MT Ke, Y Nakai, S Fujimoto, R Takayama, S Yoshida… - Cell reports, 2016 - cell.com
Super-resolution imaging deep inside tissues has been challenging, as it is extremely
sensitive to light scattering and spherical aberrations. Here, we report an optimized optical …

A complete temporal transcription factor series in the fly visual system

N Konstantinides, I Holguera, AM Rossi, A Escobar… - Nature, 2022 - nature.com
The brain consists of thousands of neuronal types that are generated by stem cells
producing different neuronal types as they age. In Drosophila, this temporal patterning is …

[HTML][HTML] The comprehensive connectome of a neural substrate for 'ON' motion detection in Drosophila

S Takemura, A Nern, DB Chklovskii, LK Scheffer… - Elife, 2017 - elifesciences.org
Analysing computations in neural circuits often uses simplified models because the actual
neuronal implementation is not known. For example, a problem in vision, how the eye …

Processing properties of ON and OFF pathways for Drosophila motion detection

R Behnia, DA Clark, AG Carter, TR Clandinin… - Nature, 2014 - nature.com
The algorithms and neural circuits that process spatio-temporal changes in luminance to
extract visual motion cues have been the focus of intense research. An influential model, the …

Temporal patterning of Drosophila medulla neuroblasts controls neural fates

X Li, T Erclik, C Bertet, Z Chen, R Voutev, S Venkatesh… - Nature, 2013 - nature.com
In the Drosophila optic lobes, the medulla processes visual information coming from inner
photoreceptors R7 and R8 and from lamina neurons. It contains approximately 40,000 …