[HTML][HTML] Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
LncRNA‐mediated posttranslational modifications and reprogramming of energy metabolism in cancer
YT Tan, JF Lin, T Li, JJ Li, RH Xu… - Cancer …, 2021 - Wiley Online Library
Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism
has historically been considered a general phenomenon of tumors. It is well recognized that …
has historically been considered a general phenomenon of tumors. It is well recognized that …
[HTML][HTML] The role of ubiquitination and deubiquitination in cancer metabolism
T Sun, Z Liu, Q Yang - Molecular cancer, 2020 - Springer
Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …
Cancer metabolism and tumor microenvironment: fostering each other?
The changes associated with malignancy are not only in cancer cells but also in
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …
[HTML][HTML] DNA-methylation-mediated activating of lncRNA SNHG12 promotes temozolomide resistance in glioblastoma
C Lu, Y Wei, X Wang, Z Zhang, J Yin, W Li, L Chen… - Molecular cancer, 2020 - Springer
Background Accumulating evidence shows that long noncoding RNAs (lncRNAs) are
important regulator molecules involved in diverse biological processes. Acquired drug …
important regulator molecules involved in diverse biological processes. Acquired drug …
[HTML][HTML] Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies
Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …
[HTML][HTML] The metastasizing mechanisms of lung cancer: recent advances and therapeutic challenges
Lung cancer is one of the common malignant tumors that threaten human life with serious
incidence and high mortality. According to the histopathological characteristics, lung cancer …
incidence and high mortality. According to the histopathological characteristics, lung cancer …
[HTML][HTML] Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression
X Zang, J Gu, J Zhang, H Shi, S Hou, X Xu… - Cell death & …, 2020 - nature.com
Abstract Long non-coding RNAs (LncRNAs) have been suggested as important regulators of
cancer development and progression in non-small cell lung cancer (NSCLC). Nevertheless …
cancer development and progression in non-small cell lung cancer (NSCLC). Nevertheless …
Long noncoding RNA MALAT1 regulates cancer glucose metabolism by enhancing mTOR-mediated translation of TCF7L2
Reprogrammed glucose metabolism of enhanced aerobic glycolysis (or the Warburg effect)
is known as a hallmark of cancer. The roles of long noncoding RNAs (lncRNA) in regulating …
is known as a hallmark of cancer. The roles of long noncoding RNAs (lncRNA) in regulating …
[HTML][HTML] Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy
Q Cai, S Wang, L Jin, M Weng, D Zhou, J Wang… - Molecular cancer, 2019 - Springer
Background Gallbladder cancer is the most common biliary tract malignancy and not
sensitive to chemotherapy. Autophagy is an important factor prolonging the survival of …
sensitive to chemotherapy. Autophagy is an important factor prolonging the survival of …