Streptococcus pneumoniae (S. pneumoniae, pneumococcus) is a Gram-positive bacterium,
which can cause a variety of diseases including otitis media, nasosinusitis, pneumonia …

Over the past few decades, the complexity of molecular entities being advanced for
therapeutic purposes has continued to evolve. A main propellent fueling innovation is the …

Several vaccines targeting bacterial pathogens show reduced efficacy upon concurrent viral
infection, indicating that a new vaccinology approach is required. To identify antigens for the …

The strength of the immune response, as measured by antibody concentrations, varies
between pneumococcal conjugate vaccines (PCVs). Linking immunogenicity and …

Background The potential impact of new pneumococcal conjugate vaccines (PCVs) is
assessed by using immune responses to predict their effectiveness against invasive …

Background Invasive pneumococcal disease (IPD), which is caused by Streptococcus
pneumoniae, has been a nationally notifiable disease in Canada since 2000. The use of …

Recruitment of plasminogen is an important infection strategy of the human pathogen
Streptococcus pneumoniae to invade host tissues. In Streptococcus aureus, triosephosphate …

Background Next-generation, higher-valency pneumococcal conjugate vaccines (PCVs), 15-
valent PCV V114 and 20-valent PCV (PCV20), have been assessed by comparing their …

Two plasminogen binding proteins were identified from a mouse infected with Streptococcus
pneumoniae. The pneumococcal proteins were annotated as ATP‐dependent Clp protease …

Background Streptococcus pneumoniae remains a leading cause of morbidity and mortality
worldwide. In this study, we sought to analyze serotype distributions, antibiotic resistance …