The microenvironment characteristics of solid tumors, renowned as barriers that harshly
impeded many drug-delivery approaches, were precisely studied, investigated, categorized …

Publisher Summary Cancer progression and metastasis are complex processes associated
with multiple and highly organized sequential steps that are both well coordinated and …

Cell plasticity regulated by the balance between the mesenchymal to epithelial transition
(MET) and the opposite program, EMT, is critical in the metastatic cascade. Several …

In the last few decades, hyaluronic acid (HA) has become increasingly employed as a
biomaterial in both clinical and research applications. The abundance of HA in many …

Hyaluronan (HA) is a glycosaminoglycan polymer that often accumulates in malignancy.
Megadalton complexes of HA with proteoglycans create a hydrated connective tissue matrix …

Publisher Summary Elevated amounts of hyaluronan (HA) correlate with several types of
malignancies. Levels of HA within cancer cells, on the surface of tumor cells, and in their …

Hyaluronidases are a family of five human enzymes that have been differentially implicated
in the progression of many solid tumor types, both clinically and in functional studies …

Despite tremendous progress in cancer immunotherapy for solid tumors, clinical success of
monoclonal antibody (mAb) therapy is often limited by poorly understood mechanisms …

Various anti-tumor nanomedicines have been developed based on the enhanced
permeability and retention effect. However, the dense extracellular matrix (ECM) in tumors …

The tumor cell–derived hyaluronidase (HAase) HYAL-1 degrades hyaluronic acid (HA) into
proangiogenic fragments that support tumor progression. Although HYAL-1 is a critical …