Combination antiretroviral therapy (cART) against HIV infection dramatically reduces AIDS-
related morbidity. However, many patients under cART display HIV-associated …

Adipose tissue redistribution occurred at first in HIV-infected patients about 15 years ago
after initiation of combination antiretroviral treatment (ART) and the responsibility of drugs …

Background. Lipoatrophy and metabolic complications of treatment of human
immunodeficiency virus (HIV) infection may share common associations with adipose tissue …

Background Long-term use of both zidovudine (AZT) and stavudine (d4T) is associated with
lipoatrophy, but it occurs possibly through different mechanisms Methods Surgical biopsy …

Background Abnormal lipid metabolism and cell oxidative mechanisms are reported in
patients on antiretroviral treatment. We compared the expression of several key adipocyte …

Although the pathogenesis of HIV lipohypertrophy remains unclear, several theories and
observations have led to the development of treatment strategies to counter fat accumulation …

Examination of adipose tissue biology may provide important insight into mechanistic links
for the observed association between higher body fat and risk of several types of cancer, in …

Although noted early in the HIV epidemic, metabolic abnormalities came to prominence
when potent combination antiretroviral therapy was introduced. Complications associated …

Background and Purpose Antiretroviral (ARV) drugs activate pregnane X receptors and
constitutive androstane receptors, increasing the risk of drug interactions due to altered drug …

The present study aimed to evaluate the role of genetic polymorphisms in the emergence of
lipoatrophy or lipodystrophy in HIV-infected patients with antiretroviral therapy (ART) in …