Importance Globular glial tauopathies (GGTs), as defined by a consensus study in 2013,
belong to the group of frontotemporal lobar degenerations and expand the spectrum of glial …

Techniques for clinical genetic testing in dementia disorders have advanced rapidly but
remain to be more widely implemented in practice. A positive genetic test offers a precise …

Background and Objective Mutations in the MAPT gene cause frontotemporal dementia
(FTD). Most previous studies investigating the neuroanatomical signature of MAPT …

Frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and vascular dementia
(VaD) are the most common forms of dementia after Alzheimer's disease (AD). The …

Objective MAPT mutations typically cause behavioral variant frontotemporal dementia with
or without parkinsonism. Previous studies have shown that symptomatic MAPT mutation …

Objective Despite the strong genetic component of frontotemporal dementia (FTD), a
substantial proportion of patients remain genetically unresolved. We performed an in-depth …

Genetic frontotemporal lobar degeneration caused by autosomal dominant gene mutations
provides an opportunity for targeted drug development in a highly complex and clinically …

Introduction The presymptomatic phase of neurodegenerative disease can last many years,
with sustained cognitive function despite progressive atrophy. We investigate this …

Unlike familial Alzheimer's disease, we have been unable to accurately predict symptom
onset in presymptomatic familial frontotemporal dementia (f-FTD) mutation carriers, which is …

Objective To determine relative frequencies and linguistic profiles of primary progressive
aphasia (PPA) variants associated with GRN (progranulin) mutations and to study their …