Many examples of the emergence or re-emergence of infectious diseases involve the
adaptation of zoonotic viruses to new amplification hosts or to humans themselves. These …

West Nile virus (WNV), like the dengue virus (DENV) and yellow fever virus (YFV), are major
arboviruses belonging to the Flavivirus genus. WNV is emerging or endemic in many …

The recent emergence of Zika virus (ZIKV) in the Americas coincident with increased
caseloads of microcephalic infants and Guillain-Barre syndrome has prompted a flurry of …

Background. The first comparison of a live RNA viral vaccine strain to its wild-type parental
strain by deep sequencing is presented using as a model the yellow fever virus (YFV) live …

West Nile virus (WNV, Flaviviridae, Flavivirus) is a mosquito-borne flavivirus introduced to
North America in 1999. Since 1999, the Earth's average temperature has increased by 0.6° …

Zika virus (ZIKV) has quietly circulated in Africa and Southeast Asia for the past 65 years.
However, the recent ZIKV epidemic in the Americas propelled this mosquito-borne virus to …

High rates of error-prone replication result in the rapid accumulation of genetic diversity of
RNA viruses. Recent studies suggest that mutation rates are selected for optimal viral fitness …

Highlights•WNV populations encounter several bottlenecks during systemic mosquito
infection.•Genetic diversity can be rapidly recovered by RNAi-mediated diversifying …

Arthropod-borne viruses (arboviruses) are transmitted by hematophagous insects, primarily
mosquitoes. The geographic range and prevalence of mosquito-borne viruses and their …

Aim: This study aims to provide insight into the binding features of the ATPase and ssRNA
sites of the NS3 helicase. Methods: Clinically approved Flavivirus inhibitors were docked to …