Background Promoter hypermethylation of tumour suppressor genes is frequently observed
during the malignant transformation of colorectal cancer (CRC). However, whether this …

Aneuploidy, a state of chromosome imbalance, is a hallmark of human tumors, but its role in
cancer still remains to be fully elucidated. To understand the consequences of whole …

Background. Malignant tumor is one of the most common diseases that seriously affect
human health. The prior literature has reported the biological function and potential …

Tumours exhibit significant heterogeneity in their molecular profiles across patients, largely
influenced by the tissue of origin, where certain driver gene mutations are predominantly …

A significant proportion of breast cancer cases are characterized by hormone receptor
positivity (HR+). Clinically, the heterogeneity of HR+ breast cancer leads to different …

Few recurrent DNA mutations are seen in aggressive canine B cell lymphomas (cBCL),
suggesting other frequent drivers. The methylated island recovery assay (MIRA-seq) or …

Cancer involves dynamic changes caused by (epi) genetic alterations such as mutations or
abnormal DNA methylation patterns which occur in cancer driver genes. These driver genes …

Cancers are diseases caused by genetic and non-genetic environmental factors. Epigenetic
alterations, some attributed to non-genetic factors, can lead to cancer development …

Protein complexes are dynamic assemblies in which proteins bind each other in different
physiological cell conditions and stoichiometries to perform cellular functions. Failures in …

DNA methylation is a biological process that adds methyl groups to DNA molecules. It
regulates chromatin architecture and transcription, and plays essential roles in a wide range …