The links between early life stress (ELS) and the emergence of psychopathology such as
increased anxiety and depression are now well established, although the specific …

Depression is the most common type of neuropsychiatric illness and has increasingly
become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 …

NG2 glia, also known as oligodendrocyte precursor cells (OPCs), play an important role in
proliferation and give rise to myelinating oligodendrocytes during early brain development …

Glutamate (Glu) and gamma-aminobutyric acid (GABA) are implicated in the
pathophysiology of major depressive disorder (MDD). GABA levels or GABAergic …

Innate defensive behaviors, such as freezing, are adaptive for avoiding predation. Freezing-
related midbrain regions project to the cerebellum, which is known to regulate rapid …

The rising incidence of postoperative depression (POD) in recent years has placed a heavy
burden on patients' physical and mental health. At this point in time, however, POD …

Adolescence is a time of significant neurocognitive development. Prolonged maturation of
prefrontal cortex (PFC) through adolescence has been found to support improvements in …

Stress-related psychiatric disorders including depression involve complex cellular and
molecular changes in the brain, and GABAergic signaling dysfunction is increasingly …

Recent neuroimaging studies suggest that the ventromedial prefrontal cortex (vmPFC)
contributes to regulation of emotion. However, the adaptive response of the vmPFC under …

Stress has profound effects on fear extinction, a form of learning that is essential to
behavioral therapies for trauma-related and stressor-related disorders. Recent work reveals …