Pharmacokinetics and pharmacodynamics of cyclodextrin-based oral drug delivery formulations for disease therapy

H Liu, S Guo, S Wei, J Liu, B Tian - Carbohydrate Polymers, 2024 - Elsevier
Oral drug administration has become the most common and preferred mode of disease
treatment due to its good medication adherence and convenience. For orally administered …

[HTML][HTML] Machine Learning Techniques Applied to the Study of Drug Transporters

X Kong, K Lin, G Wu, X Tao, X Zhai, L Lv, D Dong… - Molecules, 2023 - mdpi.com
With the advancement of computer technology, machine learning-based artificial
intelligence technology has been increasingly integrated and applied in the fields of …

Refinement of safety and efficacy of anti-cancer chemotherapeutics by tailoring their site-specific intracellular bioavailability through transporter modulation

P Dhakne, M Pillai, S Mishra, B Chatterjee… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Low intracellular bioavailability, off-site toxicities, and multi drug resistance (MDR) are the
major constraints involved in cancer chemotherapy. Many anticancer molecules fail to …

Design of chimeric GLP-1A using oligomeric bile acids to utilize transporter-mediated endocytosis for oral delivery

S Kweon, JH Lee, SB Yang, SJ Park, L Subedi… - Biomaterials …, 2023 - spj.science.org
Background Despite the effectiveness of glucagon-like peptide-1 agonist (GLP-1A) in the
treatment of diabetes, its large molecular weight and high hydrophilicity result in poor …

[HTML][HTML] Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer's Disease Management

S Dighe, S Jog, M Momin, S Sawarkar, A Omri - Pharmaceutics, 2023 - mdpi.com
Alzheimer's disease, a progressive neurodegenerative condition, is characterized by a
gradual decline in cognitive functions. Current treatment approaches primarily involve the …

[HTML][HTML] Polymer-Based Drug Delivery Systems for Cancer Therapeutics

L Ding, P Agrawal, SK Singh, YS Chhonker, J Sun… - Polymers, 2024 - mdpi.com
Chemotherapy together with surgery and/or radiotherapy are the most common therapeutic
methods for treating cancer. However, the off-target effects of chemotherapy are known to …

Structure of the Blood Brain Barrier and its Role in the Transporters for the Movement of Substrates across the Barriers

A Singh S, C Vellapandian - Current Drug Metabolism, 2023 - ingentaconnect.com
For the brain to operate normally and to develop with structural integrity in addition to
neuronal function, blood-brain barrier present in brain capillaries serves as a vital barrier …

Nano-Osmolyte Conjugation: Tailoring the Osmolyte-Protein Interactions at the Nanoscale

H Sharma, TA Dar, YS Wijayasinghe, D Sahoo… - ACS …, 2023 - ACS Publications
Osmolytes are small organic compounds accumulated at higher concentrations in the cell
under various stress conditions like high temperature, high salt, high pressure, etc …

Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily

D Digles, A Ingles-Prieto, V Dvorak… - Frontiers in …, 2024 - frontiersin.org
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily
responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human …

Investigating the Transepithelial Transport and Enzymatic Stability of Lactononadecapeptide (NIPPLTQTPVVVPPFLQPE), a 19-Amino Acid Casein-Derived Peptide in …

E Nakatani, M Sasai, H Miyazaki… - Journal of Agricultural …, 2024 - ACS Publications
Lactononadecapeptide (LNDP; NIPPLTQTPVVVPPFLQPE), a casein-derived peptide
comprising 19 residues, is known for its capacity to enhance cognitive function. This study …