[HTML][HTML] Animal models of Alzheimer's disease: Applications, evaluation, and perspectives

ZY Chen, Y Zhang - Zoological Research, 2022 - ncbi.nlm.nih.gov
Although great advances in elucidating the molecular basis and pathogenesis of
Alzheimer's disease (AD) have been made and multifarious novel therapeutic approaches …

Metabolic methanol: molecular pathways and physiological roles

YL Dorokhov, AV Shindyapina… - Physiological …, 2015 - journals.physiology.org
Methanol has been historically considered an exogenous product that leads only to
pathological changes in the human body when consumed. However, in normal, healthy …

Advance of sporadic Alzheimer's disease animal models

L Zhang, C Chen, MSH Mak, J Lu, Z Wu… - Medicinal research …, 2020 - Wiley Online Library
Abstract Alzheimer's disease (AD), the most common form of dementia, is a progressive
neurodegenerative disease. In the past decades, numbers of promising drug candidates …

Formaldehyde and brain disorders: a meta-analysis and bioinformatics approach

I Rana, L Rieswijk, C Steinmaus, L Zhang - Neurotoxicity research, 2021 - Springer
While there is significant investigation and investment in brain and neurodegenerative
disease research, current understanding of the etiologies of illnesses like Alzheimer's …

[HTML][HTML] Genetically modified large animal models for investigating neurodegenerative diseases

W Yang, X Chen, S Li, XJ Li - Cell & Bioscience, 2021 - Springer
Neurodegenerative diseases represent a large group of neurological disorders including
Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's …

Formaldehyde, epigenetics, and Alzheimer's disease

F Wang, D Chen, P Wu, C Klein… - Chemical research in …, 2019 - ACS Publications
Alzheimer's disease (AD) is the most common form of dementia. The accumulation of β-
amyloid plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau protein …

[HTML][HTML] Resveratrol attenuates formaldehyde induced hyperphosphorylation of tau protein and cytotoxicity in N2a cells

X He, Z Li, JD Rizak, S Wu, Z Wang, R He… - Frontiers in …, 2017 - frontiersin.org
Recent studies have demonstrated that formaldehyde (FA)—induced neurotoxicity is
important in the pathogenesis of Alzheimer's disease (AD). Elevated levels of FA have been …

[HTML][HTML] Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress

XL Zhang, P Wei, HU Xin-Tian, LI Jia-Li… - Zoological …, 2014 - ncbi.nlm.nih.gov
Non-human primates (NHPs) are phylogenetically close to humans, with many similarities in
terms of physiology, anatomy, immunology, as well as neurology, all of which make them …

[HTML][HTML] Formaldehyde and de/methylation in age-related cognitive impairment

T Li, Y Wei, M Qu, L Mou, J Miao, M Xi, Y Liu, R He - Genes, 2021 - mdpi.com
Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and
is usually considered as a pollutant. In the human body, FA is a product of various metabolic …

Toxicant exposure and bioaccumulation: a common and potentially reversible cause of cognitive dysfunction and dementia

SJ Genuis, KL Kelln - Behavioural neurology, 2015 - Wiley Online Library
Juxtaposed alongside the ongoing rise in the incidence and prevalence of dementia, is the
surge of recent research confirming widespread exposure and bioaccumulation of chemical …