The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Inflammasomes are multi-component signaling complexes critical to the initiation of
pyroptotic cell death in response to invading pathogens and cellular damage. A number of …

Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection
and ultimately involves the recruitment and retention of cells of hematopoietic origin, which …

Summary The interleukin (IL)‐1 family of cytokines is currently comprised of 11 members
that have pleiotropic functions in inflammation and cancer. IL‐1α and IL‐1β were the first …

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

The vertebrate transcription factor NF-κB is induced by over 150 different stimuli. Active NF-
κB, in turn, participates in the control of transcription of over 150 target genes. Because a …

Constitutive Kras and NF-κB activation is identified as signature alterations in pancreatic
ductal adenocarcinoma (PDAC). However, how NF-κB is activated in PDAC is not yet …

Virus infections induce a proinflammatory response including expression of cytokines and
chemokines. The subsequent leukocyte recruitment and antiviral effector functions …

Abstract Interleukin-10 (IL-10) is an important regulatory cytokine whose involvement
extends into diverse areas of the human immune system. Recent characterization of the …

Chemotherapy and radiation therapy (RT) are standard therapeutic modalities for patients
with cancers, and could induce various tumor cell death modalities, releasing tumor-derived …