[HTML][HTML] Cell type-specific roles of NF-κB linking inflammation and thrombosis

M Mussbacher, M Salzmann, C Brostjan… - Frontiers in …, 2019 - frontiersin.org
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

[HTML][HTML] Toward targeting inflammasomes: insights into their regulation and activation

S Christgen, DE Place, TD Kanneganti - Cell research, 2020 - nature.com
Inflammasomes are multi-component signaling complexes critical to the initiation of
pyroptotic cell death in response to invading pathogens and cellular damage. A number of …

Interleukin 1α and the inflammatory process

NC Di Paolo, DM Shayakhmetov - Nature immunology, 2016 - nature.com
Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection
and ultimately involves the recruitment and retention of cells of hematopoietic origin, which …

Function and regulation of IL‐1α in inflammatory diseases and cancer

A Malik, TD Kanneganti - Immunological reviews, 2018 - Wiley Online Library
Summary The interleukin (IL)‐1 family of cytokines is currently comprised of 11 members
that have pleiotropic functions in inflammation and cancer. IL‐1α and IL‐1β were the first …

The molecular basis of retinal ganglion cell death in glaucoma

M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012 - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Activators and target genes of Rel/NF-κB transcription factors

HL Pahl - Oncogene, 1999 - nature.com
The vertebrate transcription factor NF-κB is induced by over 150 different stimuli. Active NF-
κB, in turn, participates in the control of transcription of over 150 target genes. Because a …

[PDF][PDF] KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma

J Ling, Y Kang, R Zhao, Q Xia, DF Lee, Z Chang, J Li… - Cancer cell, 2012 - cell.com
Constitutive Kras and NF-κB activation is identified as signature alterations in pancreatic
ductal adenocarcinoma (PDAC). However, how NF-κB is activated in PDAC is not yet …

Molecular pathways in virus-induced cytokine production

TH Mogensen, SR Paludan - Microbiology and Molecular Biology …, 2001 - Am Soc Microbiol
Virus infections induce a proinflammatory response including expression of cytokines and
chemokines. The subsequent leukocyte recruitment and antiviral effector functions …

Mapping of the human IL10 gene and further characterization of the 5' flanking sequence

J Eskdale, D Kube, H Tesch, G Gallagher - Immunogenetics, 1997 - Springer
Abstract Interleukin-10 (IL-10) is an important regulatory cytokine whose involvement
extends into diverse areas of the human immune system. Recent characterization of the …

[HTML][HTML] Radiation-induced effects and the immune system in cancer

P Kaur, A Asea - Frontiers in oncology, 2012 - frontiersin.org
Chemotherapy and radiation therapy (RT) are standard therapeutic modalities for patients
with cancers, and could induce various tumor cell death modalities, releasing tumor-derived …