Recent advances in systems metabolic engineering
Highlights•Efficient microbial cell factories are developed by systems metabolic
engineering.•Recent advances in systems metabolic engineering tools and strategies are …
engineering.•Recent advances in systems metabolic engineering tools and strategies are …
Integration of yeast episomal/integrative plasmid causes genotypic and phenotypic diversity and improved sesquiterpene production in metabolically engineered …
The variability in phenotypic outcomes among biological replicates in engineered microbial
factories presents a captivating mystery. Establishing the association between phenotypic …
factories presents a captivating mystery. Establishing the association between phenotypic …
Flux optimization using multiple promoters in Halomonas bluephagenesis as a model chassis of the next generation industrial biotechnology
Y Ma, JW Ye, Y Lin, X Yi, X Wang, H Wang… - Metabolic …, 2024 - Elsevier
Predictability and robustness are challenges for bioproduction because of the unstable
intracellular synthetic activities. With the deeper understanding of the gene expression …
intracellular synthetic activities. With the deeper understanding of the gene expression …
A layered genetic design enables the yeast galactose regulon to respond to cyanamide
J Song, J Fan, C Fan, N He, X Ye, M Cao… - ACS Synthetic …, 2023 - ACS Publications
The commonly used expression systems in Saccharomyces cerevisiae typically rely on
either constitutive or galactose-regulated promoters. The lack of inducible systems in S …
either constitutive or galactose-regulated promoters. The lack of inducible systems in S …
Metabolic flux optimization of iterative pathways through orthogonal gene expression control: Application to the β-oxidation reversal
Balancing relative expression of pathway genes to minimize flux bottlenecks and metabolic
burden is one of the key challenges in metabolic engineering. This is especially relevant for …
burden is one of the key challenges in metabolic engineering. This is especially relevant for …
Towards consolidated bioprocessing of biomass and plastic substrates for semi-synthetic production of bio-poly (ethylene furanoate)(PEF) polymer using omics …
MN Omar, MM Minggu, NAN Muhammad… - Enzyme and Microbial …, 2024 - Elsevier
Abstract Poly (ethylene furanoate)(PEF) plastic is a 100% renewable polyester that is
currently being pursued for commercialization as the next-generation bio-based plastic. This …
currently being pursued for commercialization as the next-generation bio-based plastic. This …
Designing strong inducible synthetic promoters in yeasts
J Ishii, M Tominaga, Y Shima, K Nozaki, Y Ito… - 2024 - researchsquare.com
Inducible promoters are essential for precise control of target gene expression in synthetic
biological systems. However, engineering eukaryotic promoters is often more challenging …
biological systems. However, engineering eukaryotic promoters is often more challenging …
[PDF][PDF] Accelerating genetic sensor development, scale-up and deployment using synthetic biology
SHN Joshi, C Jenkins, D Ulaeto, TE Gorochowski - BioDesign Research - spj.science.org
Living cells are exquisitely tuned to sense and respond to changes in their environment.
Repurposing these systems to create engineered biosensors has seen growing interest in …
Repurposing these systems to create engineered biosensors has seen growing interest in …
[PDF][PDF] John Tyler Lazar
R Thyer - 2023 - repository.rice.edu
Doctor of Philosophy Page 1 RICE UNIVERSITY By A THESIS SUBMITTED IN PARTIAL
FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE APPROVED, THESIS …
FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE APPROVED, THESIS …
Design of a redox-proficient Escherichia coli for screening terpenoids and modifying cytochrome P450s
High-value terpenoids are found in plants, animals and microbes, with applications
spanning health to agriculture. However, moving their biosynthetic pathways to a new host is …
spanning health to agriculture. However, moving their biosynthetic pathways to a new host is …