[HTML][HTML] The neuroimmune axis of Alzheimer's disease
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
[HTML][HTML] The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics
SA Kent, TL Spires-Jones, CS Durrant - Acta neuropathologica, 2020 - Springer
Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …
disease (AD) and, as such, have become the focus of therapeutic development. Recent …
[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies
JM Long, DM Holtzman - Cell, 2019 - cell.com
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
[HTML][HTML] Fecal microbiota transplantation in neurological disorders
KEW Vendrik, RE Ooijevaar, PRC De Jong… - Frontiers in cellular …, 2020 - frontiersin.org
Background: Several studies suggested an important role of the gut microbiota in the
pathophysiology of neurological disorders, implying that alteration of the gut microbiota …
pathophysiology of neurological disorders, implying that alteration of the gut microbiota …
[HTML][HTML] Antibiotics, gut microbiota, and Alzheimer's disease
F Angelucci, K Cechova, J Amlerova, J Hort - Journal of neuroinflammation, 2019 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease whose various pathophysiological
aspects are still being investigated. Recently, it has been hypothesized that AD may be …
aspects are still being investigated. Recently, it has been hypothesized that AD may be …
[HTML][HTML] The microbiome as a modifier of neurodegenerative disease risk
The gut microbiome is increasingly implicated in modifying susceptibility to and progression
of neurodegenerative diseases (NDs). In this review, we discuss roles for the microbiome in …
of neurodegenerative diseases (NDs). In this review, we discuss roles for the microbiome in …
[HTML][HTML] Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies
D Seo, DM Holtzman - Experimental & molecular medicine, 2024 - nature.com
Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease. Despite
tremendous research efforts to understand this complex disease, the exact pathophysiology …
tremendous research efforts to understand this complex disease, the exact pathophysiology …
Short-chain fatty acids and lipopolysaccharide as mediators between gut dysbiosis and amyloid pathology in Alzheimer's disease
M Marizzoni, A Cattaneo, P Mirabelli… - Journal of …, 2020 - content.iospress.com
Background: Metagenomic data support an association between certain bacterial strains
and Alzheimer's disease (AD), but their functional dynamics remain elusive. Objective: To …
and Alzheimer's disease (AD), but their functional dynamics remain elusive. Objective: To …
[HTML][HTML] Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort
PN Sipilä, N Heikkilä, JV Lindbohm… - The Lancet Infectious …, 2021 - thelancet.com
Background Infections have been hypothesised to increase the risk of dementia. Existing
studies have included a narrow range of infectious diseases, relied on short follow-up …
studies have included a narrow range of infectious diseases, relied on short follow-up …
The role of sex and sex hormones in neurodegenerative diseases
E Vegeto, A Villa, S Della Torre, V Crippa… - Endocrine …, 2020 - academic.oup.com
Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …