[HTML][HTML] The neuroimmune axis of Alzheimer's disease

M Jorfi, A Maaser-Hecker, RE Tanzi - Genome Medicine, 2023 - Springer
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

[HTML][HTML] The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics

SA Kent, TL Spires-Jones, CS Durrant - Acta neuropathologica, 2020 - Springer
Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …

[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies

JM Long, DM Holtzman - Cell, 2019 - cell.com
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

[HTML][HTML] Fecal microbiota transplantation in neurological disorders

KEW Vendrik, RE Ooijevaar, PRC De Jong… - Frontiers in cellular …, 2020 - frontiersin.org
Background: Several studies suggested an important role of the gut microbiota in the
pathophysiology of neurological disorders, implying that alteration of the gut microbiota …

[HTML][HTML] Antibiotics, gut microbiota, and Alzheimer's disease

F Angelucci, K Cechova, J Amlerova, J Hort - Journal of neuroinflammation, 2019 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease whose various pathophysiological
aspects are still being investigated. Recently, it has been hypothesized that AD may be …

[HTML][HTML] The microbiome as a modifier of neurodegenerative disease risk

P Fang, SA Kazmi, KG Jameson, EY Hsiao - Cell host & microbe, 2020 - cell.com
The gut microbiome is increasingly implicated in modifying susceptibility to and progression
of neurodegenerative diseases (NDs). In this review, we discuss roles for the microbiome in …

[HTML][HTML] Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies

D Seo, DM Holtzman - Experimental & molecular medicine, 2024 - nature.com
Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease. Despite
tremendous research efforts to understand this complex disease, the exact pathophysiology …

Short-chain fatty acids and lipopolysaccharide as mediators between gut dysbiosis and amyloid pathology in Alzheimer's disease

M Marizzoni, A Cattaneo, P Mirabelli… - Journal of …, 2020 - content.iospress.com
Background: Metagenomic data support an association between certain bacterial strains
and Alzheimer's disease (AD), but their functional dynamics remain elusive. Objective: To …

[HTML][HTML] Hospital-treated infectious diseases and the risk of dementia: a large, multicohort, observational study with a replication cohort

PN Sipilä, N Heikkilä, JV Lindbohm… - The Lancet Infectious …, 2021 - thelancet.com
Background Infections have been hypothesised to increase the risk of dementia. Existing
studies have included a narrow range of infectious diseases, relied on short follow-up …

The role of sex and sex hormones in neurodegenerative diseases

E Vegeto, A Villa, S Della Torre, V Crippa… - Endocrine …, 2020 - academic.oup.com
Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …