Autophagy is a process that targets various intracellular elements for degradation.
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …

Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral …

Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …

Mouse caspase-11 and human caspase-4 and caspase-5 recognize cytosolic
lipopolysaccharide (LPS) to induce pyroptosis by cleaving the pore-forming protein …

Autophagy is a fundamental catabolic process coordinated by a network of autophagy-
related (ATG) proteins. These ATG proteins also perform an important parallel role in …

PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the
most important mechanisms in mitochondrial quality control (MQC) via the clearance of …