To what extent is there a general factor of risk preference, R, akin to g, the general factor of
intelligence? Can risk preference be regarded as a stable psychological trait? These …

Importance The aging of the US population is expected to lead to a large increase in the
number of adults with dementia, but some recent studies in the United States and other high …

Single-cell technologies measure unique cellular signatures but are typically limited to a
single modality. Computational approaches allow the fusion of diverse single-cell data …

Motivation LD score regression is a reliable and efficient method of using genome-wide
association study (GWAS) summary-level results data to estimate the SNP heritability of …

Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1 …

Social science genetics is concerned with understanding whether, how and why genetic
differences between human beings are linked to differences in behaviours and …

Identifying genetic correlations between complex traits and diseases can provide useful
etiological insights and help prioritize likely causal relationships. The major challenges …

Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait …

The vast majority of genome-wide association study (GWAS) risk loci fall in non-coding
regions of the genome. One possible hypothesis is that these GWAS risk loci alter the …

Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …