Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design
B Malone, N Urakova, EJ Snijder… - … Reviews Molecular Cell …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of
people and continues to cause massive global upheaval. Coronaviruses are positive-strand …
people and continues to cause massive global upheaval. Coronaviruses are positive-strand …
Molnupiravir: A lethal mutagenic drug against rapidly mutating severe acute respiratory syndrome coronavirus 2—A narrative review
S Masyeni, M Iqhrammullah… - Journal of Medical …, 2022 - Wiley Online Library
Broad‐spectrum antiviral agents targeting viral RNA‐dependent RNA polymerase (RdRp)
are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 …
are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 …
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant
M Pachetti, B Marini, F Benedetti, F Giudici… - Journal of translational …, 2020 - Springer
Background SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe
Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation …
Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation …
Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach
Abstract Background The Severe acute respiratory syndrome-related coronavirus 2 (SARS-
CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the …
CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the …
[PDF][PDF] Antivirals with common targets against highly pathogenic viruses
Historically, emerging viruses appear constantly and have cost millions of human lives.
Currently, climate change and intense globalization have created favorable conditions for …
Currently, climate change and intense globalization have created favorable conditions for …
SARS-CoV-2 RNA polymerase as target for antiviral therapy
A new human coronavirus named SARS-CoV-2 was identified in several cases of acute
respiratory syndrome in Wuhan, China in December 2019. On March 11 2020, WHO …
respiratory syndrome in Wuhan, China in December 2019. On March 11 2020, WHO …
Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA‐dependent RNA polymerase (RdRp) inhibition: an in-silico analysis
The sudden outburst of Coronavirus disease (COVID-19) caused by the Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) poses a massive threat to global public …
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) poses a massive threat to global public …
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory …
The efforts towards developing a potential drug against the current global pandemic, COVID-
19, have increased in the past few months. Drug development strategies to target the RNA …
19, have increased in the past few months. Drug development strategies to target the RNA …
Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi
Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …
expression representing an attractive and validated target for antibiotics. Two well-known …
In silico investigation on the inhibitory effect of fungal secondary metabolites on RNA dependent RNA polymerase of SARS-CoV-II: A docking and molecular dynamic …
KS Ebrahimi, M Ansari, MSH Moghaddam… - Computers in biology …, 2021 - Elsevier
Abstract The newly emerged Coronavirus Disease 2019 (COVID-19) rapidly outspread
worldwide and now is one of the biggest infectious pandemics in human society. In this …
worldwide and now is one of the biggest infectious pandemics in human society. In this …