Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …

The development of highly efficient and minimally toxic agents with targeting abilities toward
tumor tissues is an ongoing area of research in the fight against cancer. Different from the …

Increasing numbers of DNA structures are being revealed using biophysical, spectroscopic
and genomic methods. The diversity of transition metal complexes is also growing, as the …

Since the introduction of cisplatin to oncology in 1978, Pt (II) and Pd (II) compounds have
been intensively studied with a view to develop the improved anticancer agents. Polynuclear …

Employment of the monoanion of 2, 6-diacetylpyridine dioxime (dapdoH2) as a tridentate
chelate in palladium (II) and platinum (II) chemistry is reported. The syntheses, crystal …

Bacterial chromosome, the nucleoid, is traditionally modeled as a rosette of DNA mega-
loops, organized around proteinaceous central scaffold by nucleoid-associated proteins …

In the search for new metal-based anticancer agents as effective candidates for cisplatin, a
lot of strategies such as synthesis of cisplatin analogs, trans-platinum compounds and non …

Background Cisplatin has been widely used for the treatment of cancer and its antitumour
activity is attributed to its capacity to form DNA adducts, predominantly at guanine residues …

This study investigates the effect of three new platinum complexes: Pt2 (2, 4-
dimethylpyridine) 4 (berenil) 2 (Pt14), Pt2 (3, 4-dimethylpyridine) 4 (berenil) 2 (Pt15) and Pt2 …

The interactions between alkynylplatinum (II) terpyridine complexes 1–3 and the G-
quadruplex DNA, including c-myc and telomeric quadruplex DNA, are investigated both in …