Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in
many diverse cell types. It plays a major role in the development of inflammatory and …

It has been nearly 40 years since human T-cell leukemia virus-1 (HTLV-1), the first
oncogenic retrovirus in humans and the first demonstrable cause of cancer by an infectious …

IL-15 has a broad spectrum of biological activities. It is crucial for the development,
proliferation, survival and differentiation of multiple cells from both innate and adaptive …

Background A small fraction of Human T cell Leukemia Virus type-1 (HTLV-I) infected
subjects develop a severe form of myelopathy. It has been established that patients with …

Human T lymphotropic virus type I (HTLV-I)–associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is one outcome of infection with HTLV-I. A population association …

Among viruses the human retroviruses may be of special interest to immunologists, because
they target cells of the immune system, particularly mature CD4+ T cells, impair their function …

Background Several lines of evidence suggest that transcription factors are involved in the
pathogenesis of Multiple Sclerosis (MS) but complete mapping of the whole network has …

Abstract IFN regulatory factor (IRF)-4 is a lymphoid/myeloid-restricted member of the IRF
transcription factor family that plays an essential role in the homeostasis and function of …

Interleukins are mediators of inflammation, immunity and cancer. IL-15 is a cytokine
produced by several leukocytes including phagocytes in response to infections and other …

IL-15 is a pleiotropic and multifunctional cytokine that has a diverse array of distinct
biological effects in the body. It plays a crucial role in host defense from viral and non-viral …