[HTML][HTML] Role of the cGAS–STING pathway in systemic and organ-specific diseases
S Skopelja-Gardner, J An, KB Elkon - Nature Reviews Nephrology, 2022 - nature.com
Cells are equipped with numerous sensors that recognize nucleic acids, which probably
evolved for defence against viruses. Once triggered, these sensors stimulate the production …
evolved for defence against viruses. Once triggered, these sensors stimulate the production …
Neuropsychiatric lupus: new mechanistic insights and future treatment directions
N Schwartz, AD Stock, C Putterman - Nature Reviews Rheumatology, 2019 - nature.com
Patients with systemic lupus erythematosus (SLE) frequently show symptoms of central
nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS …
nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS …
Type I interferon inhibitor anifrolumab in active systemic lupus erythematosus (TULIP-1): a randomised, controlled, phase 3 trial
Background Type I interferons are involved in systemic lupus erythematosus (SLE)
pathogenesis. In a phase 2 trial, anifrolumab, a human monoclonal antibody to type I …
pathogenesis. In a phase 2 trial, anifrolumab, a human monoclonal antibody to type I …
Pathogenesis of human systemic lupus erythematosus: a cellular perspective
VR Moulton, A Suarez-Fueyo, E Meidan, H Li… - Trends in molecular …, 2017 - cell.com
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple
organs. A complex interaction of genetics, environment, and hormones leads to immune …
organs. A complex interaction of genetics, environment, and hormones leads to immune …
Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus
Long noncoding RNAs (lncRNAs) have recently been identified to be tightly linked to diverse
human diseases. However, our knowledge of Systemic Lupus Erythematosus (SLE)-related …
human diseases. However, our knowledge of Systemic Lupus Erythematosus (SLE)-related …
Hydroxychloroquine in rheumatic autoimmune disorders and beyond
EL Nirk, F Reggiori, M Mauthe - EMBO molecular medicine, 2020 - embopress.org
Initially used as antimalarial drugs, hydroxychloroquine (HCQ) and, to a lesser extent,
chloroquine (CQ) are currently being used to treat several diseases. Due to its cost …
chloroquine (CQ) are currently being used to treat several diseases. Due to its cost …
Taming lupus—a new understanding of pathogenesis is leading to clinical advances
Z Liu, A Davidson - Nature medicine, 2012 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …
Tofacitinib ameliorates murine lupus and its associated vascular dysfunction
Y Furumoto, CK Smith, L Blanco, W Zhao… - Arthritis & …, 2017 - Wiley Online Library
Objective Dysregulation of innate and adaptive immune responses contributes to the
pathogenesis of systemic lupus erythematosus (SLE) and its associated premature vascular …
pathogenesis of systemic lupus erythematosus (SLE) and its associated premature vascular …
[HTML][HTML] Exploring causal correlations between inflammatory cytokines and systemic lupus erythematosus: A Mendelian randomization
M Xiang, Y Wang, Z Gao, J Wang, Q Chen… - Frontiers in …, 2023 - frontiersin.org
Objectives Previous studies have reported that a few inflammatory cytokines have
associations with systemic lupus erythematosus (SLE)—for example, IL-6, IL-17, and …
associations with systemic lupus erythematosus (SLE)—for example, IL-6, IL-17, and …
[PDF][PDF] Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers
SK Lee, DG Silva, JL Martin, A Pratama, X Hu… - Immunity, 2012 - cell.com
Overactivity of the germinal center (GC) pathway resulting from accumulation of follicular
helper T (Tfh) cells causes autoimmunity, underscoring the need to understand the factors …
helper T (Tfh) cells causes autoimmunity, underscoring the need to understand the factors …