Increasing evidence has uncovered the essential roles of long noncoding RNAs (lncRNAs)
in biological and pathological functions of dendritic cells (DCs) among patients with systemic …

Immune suppressive activities exerted by regulatory T-cell subsets have several specific
functions, including self-tolerance and regulation of adaptive immune reactions, and their …

TLR-stimulated cross-presentation by conventional dendritic cells (cDCs) is important in host
defense and antitumor immunity. We recently reported that cDCs lacking the type I IFN …

The absence of stimulator of interferon genes (STING) in 129. B6. Fcgr2b-deficient mice
rescue lupus phenotypes. The administration of a STING inhibitor (ISD017) into the young …

Objectives Activation of endosomal toll-like receptor (TLR) 7 or TLR9 has been proposed as
a critical step for the initiation and development of SLE. Traditional spontaneous lupus …

Aim: We performed this meta-analysis in order to evaluate circulating interleukin-8 (IL-8)
levels in systemic lupus erythematosus (SLE) patients more accurately and explore its …

Objectives: The aim of this study was to clarify the consequences of Mx1, one of the IFN-
inducible proteins, in the peripheral blood as well as in renal tissues in patients with …

Here we report that bufalin and other cardiac glycoside inhibitors of the sodium-potassium
ATPase (sodium pump) potently inhibit the induction of the interferon-β (IFNβ) gene by virus …

Objective This study was performed to investigate the therapeutic effects of iguratimod in a
lupus mouse model. Methods Female MRL/lpr mice were treated with iguratimod, vehicle …

S ystemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple
alterations affecting the normal function of immune cells, such as lymphocytes, dendritic …