Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology
with a complex pathogenesis involving multiple genetic and environmental contributions …

STAT4 has been consistently associated with several autoimmune diseases, including
rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The aim of this study was …

Patients with systemic lupus erythematosus (SLE) display an activated type I IFN system due
to unceasing IFN-α release from plasmacytoid dendritic cells (pDCs) stimulated by nucleic …

Systemic autoimmune and rheumatic diseases (SAIRDs) are thought to develop due to the
failure of autoimmune regulation and tolerance. Current therapies, such as biologics, have …

Systemic lupus erythematosus (SLE) is a chronic, devastating autoimmune disorder
associated with severe organ damage. Recently, the role of Signal Transducer and Activator …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve
several organs. The disease is characterized by a recurring pattern of remission and flare …

Introduction Nigella sativa L. is an herbal plant with Thimoquinone as the main therapeutic
properties. This plants has been shown to cure for various diseases and affected the …

Background and aim: tumor necrosis factor (TNF)-plays a significant role in the
pathogenesis of nonalcoholic steatohepatitis (NASH). A few studies have confirmed high …

Chronic inflammation causes target organ damage in patients with systemic autoimmune
diseases. The factors that allow this protracted response are poorly understood. We …

Treatment of patients with Systemic Lupus Erythematosus (SLE) who have active disease
refractory to current therapeutic strategies continues to be a real challenge. Here, we …