[HTML][HTML] Epigenetic modification of m6A regulator proteins in cancer

Y Wang, Y Wang, H Patel, J Chen, J Wang, ZS Chen… - Molecular Cancer, 2023 - Springer
Abstract Divergent N6-methyladenosine (m6A) modifications are dynamic and reversible
posttranscriptional RNA modifications that are mediated by m6A regulators or m6A RNA …

[HTML][HTML] Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

[HTML][HTML] The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities

RB Damgaard - Cell Death & Differentiation, 2021 - nature.com
Forty years ago, ubiquitin was first discovered as a posttranslational modification earmarking
proteins for degradation [1]. This seminal, biochemical work laid the foundation for countless …

The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

C Sampson, Q Wang, W Otkur, H Zhao… - Clinical and …, 2023 - Wiley Online Library
Ubiquitination is one of the most important post‐translational modifications which plays a
significant role in conserving the homeostasis of cellular proteins. In the ubiquitination …

METTL5 stabilizes c‐Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression

P Xia, H Zhang, H Lu, K Xu, X Jiang… - Cancer …, 2023 - Wiley Online Library
Background Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in the
world, with a high likelihood of metastasis and a dismal prognosis. The reprogramming of …

USP25 ameliorates pathological cardiac hypertrophy by stabilizing SERCA2a in cardiomyocytes

B Ye, H Zhou, Y Chen, W Luo, W Lin, Y Zhao… - Circulation …, 2023 - Am Heart Assoc
Background: Pathological cardiac hypertrophy can lead to heart failure and is one of the
leading causes of death globally. Understanding the molecular mechanism of pathological …

To Ub or not to Ub: a regulatory question in TGF-β signaling

J Liu, J Jin, T Liang, XH Feng - Trends in Biochemical Sciences, 2022 - cell.com
The transforming growth factor β (TGF-β) superfamily controls a wide spectrum of biological
processes in metazoans, including cell proliferation, apoptosis, differentiation, cell-fate …

[HTML][HTML] Therapeutic potential of mesenchymal stem/stromal cells (MSCs)-based cell therapy for inflammatory bowel diseases (IBD) therapy

MJ Saadh, MV Mikhailova, S Rasoolzadegan… - European Journal of …, 2023 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) therapy has become an emerging
therapeutic modality for the treatment of inflammatory bowel disease (IBD), given their …

[HTML][HTML] LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2

J Wang, Z He, X Liu, J Xu, X Jiang, G Quan… - Cell death & …, 2022 - nature.com
Recently, long non-coding RNAs (lncRNA) have been proven to regulate pancreatic cancer
(PC) progression. We aimed to explore the pathogenesis of LINC00941 in PC regarding …

Proteomics of post-translational modifications in colorectal cancer: Discovery of new biomarkers

G Zhu, L Jin, W Sun, S Wang, N Liu - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Colorectal cancer (CRC) is one of the costliest health problems and ranks second in cancer-
related mortality in developed countries. With the aid of proteomics, many protein …