Recognizing COVID-19–related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management

B Siripanthong, S Nazarian, D Muser, R Deo… - Heart rhythm, 2020 - Elsevier
Human coronavirus-associated myocarditis is known, and a number of coronavirus disease
19 (COVID-19)–related myocarditis cases have been reported. The pathophysiology of …

Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa

KA Khan, RS Kerbel - Nature Reviews Clinical Oncology, 2018 - nature.com
Immunotherapies have revolutionized medical oncology following the remarkable and, in
some cases, unprecedented outcomes observed in certain groups of patients with cancer …

Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis

A Barmada, J Klein, A Ramaswamy, NN Brodsky… - Science …, 2023 - science.org
Rare immune-mediated cardiac tissue inflammation can occur after vaccination, including
after SARS-CoV-2 mRNA vaccines. However, the underlying immune cellular and molecular …

[HTML][HTML] A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair

K Sun, Y Li, J Jin - Signal transduction and targeted therapy, 2021 - nature.com
The response of immune cells in cardiac injury is divided into three continuous phases:
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …

Single-cell sequencing of mouse heart immune infiltrate in pressure overload–driven heart failure reveals extent of immune activation

E Martini, P Kunderfranco, C Peano, P Carullo… - Circulation, 2019 - Am Heart Assoc
Background: Inflammation is a key component of cardiac disease, with macrophages and T
lymphocytes mediating essential roles in the progression to heart failure. Nonetheless, little …

COVID-19 vaccine-induced myocarditis: case report with literature review

M Nassar, N Nso, C Gonzalez, S Lakhdar… - Diabetes & Metabolic …, 2021 - Elsevier
Myocarditis is the progressive inflammation of the middle layer of the heart followed by a
myocardial injury without ischemic events [1, 2]. The infectious and non-infectious causes of …

Immunometabolic mechanisms of heart failure with preserved ejection fraction

GG Schiattarella, P Alcaide, G Condorelli… - Nature cardiovascular …, 2022 - nature.com
Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide,
already accounting for at least half of all cases of heart failure. As most patients with HFpEF …

Myocardial aging as a T-cell–mediated phenomenon

GC Ramos, A van den Berg… - Proceedings of the …, 2017 - National Acad Sciences
In recent years, the myocardium has been rediscovered under the lenses of immunology,
and lymphocytes have been implicated in the pathogenesis of cardiomyopathies with …

T-cell recruitment to the heart: friendly guests or unwelcome visitors?

RM Blanton, FJ Carrillo-Salinas… - American Journal of …, 2019 - journals.physiology.org
Myocardial inflammation can lead to lethal acute or chronic heart failure (HF). T lymphocytes
(T cells), have been reported in the inflamed heart in different etiologies of HF, and more …

Cellular and molecular mechanisms of HGF/Met in the cardiovascular system

S Gallo, V Sala, S Gatti, T Crepaldi - Clinical science, 2015 - portlandpress.com
Met tyrosine kinase receptor, also known as c-Met, is the HGF (hepatocyte growth factor)
receptor. The HGF/Met pathway has a prominent role in cardiovascular remodelling after …