X-linked hypophosphataemia (XLH) is the most frequent cause of hypophosphataemia-
associated rickets of genetic origin and is associated with high levels of the phosphaturic …

The term “vitamin D dependent rickets” describes a group of genetic disorders that are
characterized by early-onset rickets due to the inability to maintain adequate concentrations …

Context Younger age at treatment onset with conventional therapy (phosphate salts and
active vitamin D; Pi/D) is associated with improved growth and skeletal outcomes in children …

Abstract Tumor-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a
rare acquired paraneoplastic disease that is challenging to diagnose and treat. TIO is …

Among bone-material qualities, mineralization is pivotal in conferring stiffness and
toughness to the bone. Osteomalacia, a disease ensuing from inadequate mineralization of …

X-linked hypophosphatemia (XLH) is the most common genetic form of hypophosphatemic
rickets and osteomalacia. In this disease, mutations in the PHEX gene lead to elevated …

Hypophosphatemic rickets typically presents in infancy or early childhood with skeletal
deformities and growth plate abnormalities. The most common causes are genetic (such as …

Biomineralization is remarkably diverse and provides myriad functions across many
organismal systems. Biomineralization processes typically produce hardened, hierarchically …

Purpose Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal
phosphate and vitamin D metabolism caused by typically small endocrine tumors that …

Rickets refers to a deficient mineralization of the growth plate cartilage, predominantly
affecting longer bones. Despite the fact that preventive measures are available, it is still a …