Infections caused by antibiotic-resistant bacteria (ARB) are one of the major global health
challenges of our time. In addition to developing new antibiotics to combat ARB, sensitizing …

Since Fleming's discovery of penicillin nearly a century ago, a bounty of natural product
antibiotics have been discovered, many of which continue to be of clinical importance today …

Drug‐resistant bacteria and biofilm‐associated infections are prominent problems in the
field of antibacterial medicine, seriously affecting human and animal health. Despite the …

Antimicrobial resistance is a leading mortality factor worldwide. Here, we report the
discovery of clovibactin, an antibiotic isolated from uncultured soil bacteria. Clovibactin …

Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by
the classic membrane permeabilization model. Recently, the clinically vital but also highly …

Rhomboid proteases hydrolyze substrate helices within the lipid bilayer to release soluble
domains from the membrane. Here, we investigate the mechanism of activity regulation for …

A class of piperazine hybridized coumarin indolylcyanoenones was exploited as new
structural antibacterial frameworks to combat intractable bacterial resistance. Bioactive …

Solid-state nuclear magnetic resonance (ssNMR) methods can probe the motions of
membrane proteins in liposomes at the atomic level and propel the understanding of …

Antimicrobial resistance is a leading cause of mortality, calling for the development of new
antibiotics. The fungal antibiotic plectasin is a eukaryotic host defence peptide that blocks …

Antimicrobial peptides (AMPs) commonly target bacterial membranes and show broad-
spectrum activity against microorganisms. In this research we used three AMPs (nisin …