Genetic basis for congenital heart disease: revisited: a scientific statement from the American Heart Association
This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …
Opportunities and challenges of whole-genome and-exome sequencing
BS Petersen, B Fredrich, MP Hoeppner, D Ellinghaus… - BMC genetics, 2017 - Springer
Recent advances in the development of sequencing technologies provide researchers with
unprecedented possibilities for genetic analyses. In this review, we will discuss the history of …
unprecedented possibilities for genetic analyses. In this review, we will discuss the history of …
Species-specific segmentation clock periods are due to differential biochemical reaction speeds
M Matsuda, H Hayashi, J Garcia-Ojalvo… - Science, 2020 - science.org
Although mechanisms of embryonic development are similar between mice and humans,
the time scale is generally slower in humans. To investigate these interspecies differences in …
the time scale is generally slower in humans. To investigate these interspecies differences in …
Immunogenicity of induced pluripotent stem cells
Induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells with defined
factors, hold great promise for regenerative medicine as the renewable source of autologous …
factors, hold great promise for regenerative medicine as the renewable source of autologous …
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes
H Skaletsky, T Kuroda-Kawaguchi, PJ Minx… - Nature, 2003 - nature.com
The male-specific region of the Y chromosome, the MSY, differentiates the sexes and
comprises 95% of the chromosome's length. Here, we report that the MSY is a mosaic of …
comprises 95% of the chromosome's length. Here, we report that the MSY is a mosaic of …
NKX2-5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes
DA Elliott, SR Braam, K Koutsis, ES Ng, R Jenny… - Nature …, 2011 - nature.com
NKX2-5 is expressed in the heart throughout life. We targeted eGFP sequences to the NKX2-
5 locus of human embryonic stem cells (hESCs); NKX2-5 eGFP/w hESCs facilitate …
5 locus of human embryonic stem cells (hESCs); NKX2-5 eGFP/w hESCs facilitate …
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns
The nucleus is highly compartmentalized through the formation of distinct classes of
membraneless domains. However, the composition and function of many of these structures …
membraneless domains. However, the composition and function of many of these structures …
MOSAIK: a hash-based algorithm for accurate next-generation sequencing short-read mapping
MOSAIK is a stable, sensitive and open-source program for mapping second and third-
generation sequencing reads to a reference genome. Uniquely among current mapping …
generation sequencing reads to a reference genome. Uniquely among current mapping …
A physical map of the human genome.
JD McPherson, M Marra, LD Hillier, RH Waterston… - …, 2001 - search.ebscohost.com
Reports the construction of the whole-genome bacterial artificial chromosome (BAC) map
and its integration with previous landmark maps and information from mapping efforts …
and its integration with previous landmark maps and information from mapping efforts …
Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery
EC Lee, Q Liang, H Ali, L Bayliss, A Beasley… - Nature …, 2014 - nature.com
If immunized with an antigen of interest, transgenic mice with large portions of unrearranged
human immunoglobulin loci can produce fully human antigen-specific antibodies; several …
human immunoglobulin loci can produce fully human antigen-specific antibodies; several …