Checkpoint inhibitors have revolutionized cancer treatment. However, only a minority of
patients respond to these immunotherapies. Here, we report that blocking the inhibitory …

Alteration in the expression of cell-surface proteins is a common consequence of malignant
transformation. Natural killer (NK) cells use an array of germline-encoded activating and …

Originally identified in studies of cellular resistance to viral infection, interferon (IFN)-γ is now
known to represent a distinct member of the IFN family and plays critical roles not only in …

Over the last decade, various new therapies have been developed to promote anti-tumor
immunity. Despite interesting clinical results in hematological malignancies, the …

The role of angiogenesis in tumor growth has been studied continuously for over 45 years. It
is now appreciated that angiogenesis is also essential for the dissemination and …

Long noncoding RNAs play a pivotal role in T-helper cell development but little is known
about their roles in Treg differentiation and functions during the progression of …

The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …

Motivation Immune cells are important components of the immune system and are crucial for
disease initiation, progression, prognosis and survival. Although several computational …

The contribution of natural killer (NK) cells to immunosurveillance of human cancer remains
debatable. Here, we discuss advances in several areas of human NK cell research, many of …

Abstract Traditional Chinese Medicine (TCM) has been traditionally used to treat patients
with cancers in China. It not only alleviates the symptoms of tumor patients and improves …