Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …

Background Several quinoline and structurally related antimalarial drugs are associated
with cardiovascular side effects, particularly hypotension and electrocardiographic QT …

Artemisinin-based combination therapies (ACTs) have become the mainstay for malaria
treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent …

The deployment of artesunate for severe malaria and the artemisinin combination therapies
(ACTs) for uncomplicated malaria has been a major advance in antimalarial therapeutics …

Malaria is a devastating disease caused by Plasmodium parasites, resulting in
approximately 435000 deaths in 2018. The impact of malaria is compounded by the …

Equilibrative nucleoside transporters (ENTs) are present at the blood-testis barrier (BTB),
where they can facilitate antiviral drug disposition to eliminate a sanctuary site for viruses …

Background Treatment and control of malaria depends on artemisinin-based combination
therapies (ACTs) and is challenged by drug resistance, but thus far resistance to …

Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line
drug for treating malaria. Apart from treating malaria, artesunate has also been found to …

Malaria disproportionately affects children younger than 5 years. Falciparum malaria is
responsible for more than 200 000 child deaths per year in Africa and vivax malaria is well …

Malaria remains one of the most important infectious diseases in the world, with the greatest
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …