Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

During development, both cells and tissues must acquire the correct shape to allow their
proper function. This is especially relevant in the nervous system, where the shape of …

Integrins are cell adhesion receptors that are evolutionary old and that play important roles
during developmental and pathological processes. The integrin family is composed of 24 αβ …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

Cancer stem cells (CSCs) are a subpopulation of tumor cells suggested to be critical for
tumor maintenance, metastasis, and therapeutic resistance. Prospective identification and …

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal
and differentiation. In order to better understand the contribution of substrate stiffness to …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

Stroke remains a significant unmet clinical need with few treatment options that have a very
narrow therapeutic window, thereby causing massive mortality and morbidity in the United …

Physical factors in the local cellular microenvironment, including cell shape and geometry,
matrix mechanics, external mechanical forces, and nanotopographical features of the …

Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …