Prion protein (PrPC), when associated with the secreted form of the stress‐inducible protein
1 (STI1), plays an important role in neural survival, neuritogenesis, and memory formation …

The stage‐specific embryonic antigen 4 (SSEA4) is commonly used as a cell surface marker
to identify the pluripotent human embryonic stem (ES) cells. Immunohistochemistry on …

Abstract Background Neural precursor cells (NPCs) are defined by their ability to proliferate,
self-renew, and retain the potential to differentiate into neurons and glia. Deciphering the …

Biomaterial matrices presenting extracellular matrix (ECM) components in a controlled three-
dimensional configuration provide a unique system to study neural stem cell (NSC)–ECM …

The insulin-like growth factor receptor type 1 (IGF1R) signalling pathway is activated in the
mammalian nervous system from early developmental stages. Its major effect on developing …

Stem cells exhibit promise in numerous areas of regenerative medicine. Their fate and
function are governed by a combination of intrinsic determinants and signals from the local …

The characteristics of a material's surface are extremely important when considering their
interactions with biological species. Despite surface chemistry playing a critical role in …

In the mammalian adult brain, neural stem cells persist in neurogenic niches. The
subependymal zone is the most prolific neurogenic niche in adult rodents, where residing …

Neural stem cell (NSC)-based therapies offer potential for neural repair in central nervous
system (CNS) inflammatory and degenerative disorders. Typically, these conditions present …

Three-dimensional (3D) spheroids composed of brain cells have shown great potential to
mimic the pathophysiology of the brain. However, a 3D spheroidal brain-disease model for …