Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Hernia reconstruction is one of the most frequently practiced surgical procedures worldwide.
Plastic surgery plays a pivotal role in reestablishing desired abdominal wall structure and …

Tumor-associated macrophages (TAMs) play a pivotal role in the progression and
resistance of tumors to different anticancer drugs. TAMs can modulate the tumor …

In pancreatic ductal adenocarcinoma (PDAC), the abundant stromal cells which comprise
the tumor microenvironment constitute more than 90% of the primary tumor bulk. Moreover …

The extracellular matrix (ECM) is a complex network of biomolecules that mechanically and
biochemically directs cell behavior and is crucial for maintaining tissue function and health …

Genomic instability and inflammation are intricately connected hallmark features of cancer.
DNA repair defects due to BRCA1/2 mutation instigate immune signaling through the …

Conclusions The CF has recently emerged as one of the most phenotypically plastic cells in
the heart, with distinct transcriptional and secretory programs that regulate their essential …

Fibrosis can be defined as an excessive and deregulated deposition of extracellular matrix
proteins, causing loss of physiological architecture and dysfunction of different tissues and …

The basement membrane (BM) is a specialized layer of extracellular matrix components that
plays a central role in maintaining lung and kidney functions. Although the composition of …

Mechanomedicine is an emerging field focused on characterizing mechanical changes in
cells and tissues coupled with a specific disease. Understanding the mechanical cues that …