Drosophila class-I myosins that can impact left-right asymmetry have distinct ATPase kinetics
FA Báez-Cruz, EM Ostap - Journal of Biological Chemistry, 2023 - ASBMB
Myosin-1D (myo1D) is important for Drosophila left-right asymmetry, and its effects are
modulated by myosin-1C (myo1C). De novo expression of these myosins in nonchiral …
modulated by myosin-1C (myo1C). De novo expression of these myosins in nonchiral …
Cells solved the Gibbs paradox by learning to contain entropic forces
JE Baker - Scientific Reports, 2023 - nature.com
As Nature's version of machine learning, evolution has solved many extraordinarily complex
problems, none perhaps more remarkable than learning to harness an increase in chemical …
problems, none perhaps more remarkable than learning to harness an increase in chemical …
Endocytic myosin-1 is a force-insensitive, power-generating motor
Myosins are required for clathrin-mediated endocytosis, but their precise molecular roles in
this process are not known. This is, in part, because the biophysical properties of the …
this process are not known. This is, in part, because the biophysical properties of the …
Thermodynamics and Kinetics of a Binary Mechanical system: Mechanisms of muscle contraction
JE Baker - Langmuir, 2022 - ACS Publications
Biological motors function at the interface of biology, physics, and chemistry, and it remains
unsettled what rules from which disciplines account for how these motors work. Myosin …
unsettled what rules from which disciplines account for how these motors work. Myosin …
The Problem with Inventing Molecular mechanisms to Fit thermodynamic equations of muscle
J Baker - International Journal of Molecular Sciences, 2023 - mdpi.com
Almost every model of muscle contraction in the literature to date is a molecular power
stroke model, even though this corpuscular mechanism is opposed by centuries of science …
stroke model, even though this corpuscular mechanism is opposed by centuries of science …
Geldanaycin-encapsulated magnetic nanoparticle for isolation of myosin in proteomics
Q Chen, Y Xu, X Feng, Y Xiang, J Ni, G Ding, Q Ren… - Talanta, 2024 - Elsevier
The grafting of a drug molecule, ie, geldanamycin (GA) onto polyethyleneimine (PEI)-coated
magnetic nanoparticle produces a novel composite, GA@ Fe 3 O 4–NH 2. The composite is …
magnetic nanoparticle produces a novel composite, GA@ Fe 3 O 4–NH 2. The composite is …
From amino-acid to disease: the effects of oxidation on actin-myosin interactions in muscle
D Elkrief, O Matusovsky, YS Cheng… - Journal of Muscle …, 2023 - Springer
Actin-myosin interactions form the basis of the force-producing contraction cycle within the
sarcomere, serving as the primary mechanism for muscle contraction. Post-translational …
sarcomere, serving as the primary mechanism for muscle contraction. Post-translational …
Four phases of a force transient emerge from a binary mechanical system
JE Baker - Journal of Muscle Research and Cell Motility, 2024 - Springer
Accurate models of muscle contraction are important for understanding both muscle
performance and the therapeutics that enhance physiological function. However, models are …
performance and the therapeutics that enhance physiological function. However, models are …
Myosin II adjusts motility properties and regulates force production based on motor environment
OY Al Azzam, JC Watts, JE Reynolds, JE Davis… - Cellular and Molecular …, 2022 - Springer
Introduction Myosin II has been investigated with optical trapping, but single motor-filament
assay arrangements are not reflective of the complex cellular environment. To understand …
assay arrangements are not reflective of the complex cellular environment. To understand …
A chemical thermodynamic model of motor enzymes unifies chemical-Fx and powerstroke models
JE Baker - Biophysical Journal, 2022 - cell.com
Molecular motors play a central role in many biological processes, ranging from pumping
blood and breathing to growth and wound healing. Through motor-catalyzed chemical …
blood and breathing to growth and wound healing. Through motor-catalyzed chemical …