The central noradrenergic neurone, like the peripheral sympathetic neurone, is
characterized by a diffusely arborizing terminal axonal network. The central neurones …

Previous findings have implicated the noradrenergic locus coeruleus (LC) system in
functions along the dimension of arousal or attention. It has remained uncertain what role …

The locus coeruleus (LC) contains norepinephrine (NE)-synthesizing neurons that send
diffuse projections throughout the central nervous system. The LC-NE system has a major …

Norepinephrine (NE) has widespread projections throughout the brain, and thus, is ideally
positioned to orchestrate neural functions based on arousal state. For example, NE can …

Recordings from noradrenergic locus coeruleus (LC) neurons in behaving rats and monkeys
revealed that these cells decrease tonic discharge during sleep and also during certain high …

The cerebral cortex, occupying over 70 percent of our brain mass, is key to any
understanding of the workings--and disorders--of the human brain. offering a …

All neuronal circuits are subject to neuromodulation. Modulatory effects on neuronal
processing and resulting behavioral changes are most commonly reported for higher order …

The locus coeruleus (LC) is a brainstem structure that has widespread cortical and sub-
cortical projections to modulate states of attention. Our understanding of the LC's role in both …

The organization of the cortical monoamine systems, dopamine (DA), and noradrenaline
(NA), which have been studied extensively in the rat and more recently in the monkey, had …

Publisher Summary Recent work on the locus coeruleus-norepinephrine (LC-NE) system
has led us to hypothesize that it plays a central role in regulating this balance between …