Roles of tau pathology in the locus coeruleus (LC) in age-associated pathophysiology and Alzheimer's disease pathogenesis: Potential strategies to protect the LC …

A Satoh, KM Iijima - Brain research, 2019 - Elsevier
The locus coeruleus (LC) is the noradrenaline (norepinephrine, NE)-containing nucleus in
the brainstem and innervates into widespread brain regions. This LC-NE system plays a …

Development of the catecholamine neurons in human embryos and fetuses, with special emphasis on the innervaton of the cerebral cortex

N Zecevic, C Verney - Journal of Comparative Neurology, 1995 - Wiley Online Library
The cathecholaminergic (CA) systems have been described as appearing early in the
development of the mammalian central nervous system (CNS), but their exact distribution in …

Lateralization and functional organization of the locus coeruleus projection to the trigeminal somatosensory pathway in rat

KL Simpson, DW Altman, L Wang… - Journal of …, 1997 - Wiley Online Library
The primary goals of this study were to (1) examine the distribution of locus coeruleus (LC)
neurons, which project to cortical and subcortical sites along the trigeminal somatosensory …

Layer-and area-specific actions of norepinephrine on cortical synaptic transmission

H Salgado, M Treviño, M Atzori - Brain research, 2016 - Elsevier
The cerebral cortex is a critical target of the central noradrenergic system. The importance of
norepinephrine (NE) in the regulation of cortical activity is underscored by clinical findings …

Evidence for a regional specificity in the density and distribution of noradrenergic varicosities in rat cortex

KL Agster, CA Mejias‐Aponte, BD Clark… - Journal of …, 2013 - Wiley Online Library
The brainstem nucleus locus coeruleus (LC) is the sole source of norepinephrine (NE)‐
containing fibers in the mammalian cortex. Previous studies suggest that the density of …

The human locus coeruleus complex: an immunohistochemical and three dimensional reconstruction study

KG Baker, I Törk, JP Hornung, P Halasz - Experimental brain research, 1989 - Springer
The CA (catecholamine/catecholaminergic) cell populations of the locus coeruleus (LC) and
subcoeruleus (SubC) were studied using serial sections of the human brainstem …

Catecholamines and attention I: Animal and clinical studies

CR Clark, GM Geffen, LB Geffen - Neuroscience & Biobehavioral Reviews, 1987 - Elsevier
One important function of the catecholamine innervation of the cerebral cortex may be the
control of attention. Of particular interest are the catecholamine projections to the cerebral …

[HTML][HTML] The pupillary light reflex as a biomarker of concussion

FR Carrick, SF Azzolino, M Hunfalvay, G Pagnacco… - Life, 2021 - mdpi.com
The size of our pupils changes continuously in response to variations in ambient light levels,
a process known as the pupillary light reflex (PLR). The PLR is not a simple reflex as its …

[HTML][HTML] ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer's disease

CE Ramsden, D Zamora, MS Horowitz… - Acta Neuropathologica …, 2023 - Springer
In sporadic Alzheimer's disease (sAD) specific regions, layers and neurons accumulate
hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even …

Noradrenergic innervation of monkey prefrontal cortex: A dopamine‐β‐hydroxylase immunohistochemical study

DA Lewis, JH Morrison - Journal of Comparative Neurology, 1989 - Wiley Online Library
Norepinephrine has been implicated in the regulation of a number of cortical functions, yet
relatively little is known about the anatomical organization of noradrenergic axons in the …