Sepsis and septic shock

M Cecconi, L Evans, M Levy, A Rhodes - The Lancet, 2018 - thelancet.com
Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis

C Wacker, A Prkno, FM Brunkhorst… - The Lancet infectious …, 2013 - thelancet.com
Background Procalcitonin is a promising marker for identification of bacterial infections. We
assessed the accuracy and clinical value of procalcitonin for diagnosis of sepsis in critically …

The surgical infection society revised guidelines on the management of intra-abdominal infection

JE Mazuski, JM Tessier, AK May, RG Sawyer… - Surgical …, 2017 - liebertpub.com
Background: Previous evidence-based guidelines on the management of intra-abdominal
infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and …

Combination therapy for treatment of infections with gram-negative bacteria

PD Tamma, SE Cosgrove… - Clinical microbiology …, 2012 - Am Soc Microbiol
Combination antibiotic therapy for invasive infections with Gram-negative bacteria is
employed in many health care facilities, especially for certain subgroups of patients …

De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock

J Garnacho-Montero, A Gutiérrez-Pizarraya… - Intensive care …, 2014 - Springer
Purposes We set out to assess the safety and the impact on in-hospital and 90-day mortality
of antibiotic de-escalation in patients admitted to the ICU with severe sepsis or septic shock …

The diagnostic accuracy of procalcitonin and C‐reactive protein for sepsis: a systematic review and meta‐analysis

M Tan, Y Lu, H Jiang, L Zhang - Journal of cellular biochemistry, 2019 - Wiley Online Library
Background The objective of this study was to systematically evaluate the clinical value of
procalcitonin and C‐reactive protein in the diagnosis of adult patients with sepsis. Method …

Evaluation of the FilmArray blood culture identification panel: results of a multicenter controlled trial

H Salimnia, MR Fairfax, PR Lephart… - Journal of clinical …, 2016 - Am Soc Microbiol
Sepsis is a major cause of morbidity, mortality, and increased medical expense. Rapid
diagnosis improves outcomes and reduces costs. The FilmArray blood culture identification …

Gram-positive toxic shock syndromes

E Lappin, AJ Ferguson - The Lancet infectious diseases, 2009 - thelancet.com
Toxic shock syndrome (TSS) is an acute, multi-system, toxin-mediated illness, often resulting
in multi-organ failure. It represents the most fulminant expression of a spectrum of diseases …

Sepsis: mechanisms of bacterial injury to the patient

H Minasyan - Scandinavian journal of trauma, resuscitation and …, 2019 - Springer
In bacteremia the majority of bacterial species are killed by oxidation on the surface of
erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing …

Programas de optimización de uso de antimicrobianos (PROA) en hospitales españoles: documento de consenso GEIH-SEIMC, SEFH y SEMPSPH

J Rodríguez-Baño, JR Pano-Pardo… - … y Microbiología Clínica, 2012 - Elsevier
Los antimicrobianos son fármacos distintos al resto. Su eficacia en la reducción de la
morbilidad y la mortalidad es muy superior a la de otros grupos de medicamentos. Por otra …