Chronic pain exerts an enormous personal and economic burden, affecting more than 30%
of people worldwide according to some studies. Unlike acute pain, which carries survival …

Importance Mortality among people with opioid dependence is higher than that of the
general population. Opioid agonist treatment (OAT) is an effective treatment for opioid …

Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Objective Opioid use disorder (OUD), which includes the morbidity of dependence and
mortality of overdose, has reached epidemic proportions in the United States …

Abstract Purpose of Review Pharmacological therapy for acute pain carries the risk of opioid
misuse, with opioid use disorder (OUD) reaching epidemic proportions worldwide in recent …

Importance One of the main aims of research on nonmedical opioid use (NMOU) is to
reduce the frequency of NMOU behaviors through interventions such as universal …

Chronic pain is highly prevalent among adults treated with maintenance haemodialysis (HD)
and has profound negative effects. Over four decades, research has demonstrated that 50 …

Introduction In the past decades, the opioid crisis has heavily impacted parts of the US
society and has been followed by an increase in the use of opioids worldwide. It is of …

Objective: This paper examines substance and behavioral addictions among American
Indian and Alaska Natives (AIAN) to identify the structural and psychosocial risk and cultural …

Background: Opioids are frequently prescribed for acute musculoskeletal injuries and may
result in long-term use and consequent harms. Purpose: To explore factors associated with …