Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …

There has been a resurgence of interest in the use of phenotypic screens in drug discovery
as an alternative to target-focused approaches. Given that oncology is currently the most …

Introducing hydration layers to hydrogel microspheres (HMs) by coating the surface with
liposomes can effectively reduce friction. However, the lubrication can be inactivated when …

Aminoglycosides are toxic to sensory hair cells (HCs). Macroautophagy/autophagy is an
essential and highly conserved self-digestion pathway that plays important roles in the …

We describe here the main natural compounds used in cancer therapy and prevention, the
historical aspects of their application and pharmacognosy. Two major applications of these …

Presbycusis is the cumulative effect of aging on hearing. Recent studies have shown that
common mitochondrial gene deletions are closely related to deafness caused by …

Autophagy is the major intracellular degradation system, by which cytoplasmic materials are
delivered to and degraded in the lysosome. As a quality control mechanism for cytoplasmic …

The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when
genetically downregulated, increases life span in evolutionarily diverse organisms including …

Autophagy protects organelles, cells, and organisms against several stress conditions.
Induction of autophagy by resveratrol requires the nicotinamide adenine dinucleotide …

Aim of the Study mTOR inhibitors are showing promising results in the management of
vascular anomalies. Although current controlled trials remain to be completed, many …