Triazole-fused pyrimidines in target-based anticancer drug discovery
XJ Dai, LP Xue, SK Ji, Y Zhou, Y Gao, YC Zheng… - European Journal of …, 2023 - Elsevier
In recent decades, the development of targeted drugs has featured prominently in the
treatment of cancer, which is among the major causes of mortality globally. Triazole-fused …
treatment of cancer, which is among the major causes of mortality globally. Triazole-fused …
[HTML][HTML] The role of acidosis in the pathogenesis of severe forms of COVID-19
YD Nechipurenko, DA Semyonov, IA Lavrinenko… - Biology, 2021 - mdpi.com
Simple Summary Recently, several studies have shown that acidosis, which is increased
acidity in the blood and other body tissues, is often associated with severe COVID-19. In this …
acidity in the blood and other body tissues, is often associated with severe COVID-19. In this …
[HTML][HTML] Interplay of carbon dioxide and peroxide metabolism in mammalian cells
R Radi - Journal of Biological Chemistry, 2022 - ASBMB
The carbon dioxide/bicarbonate (CO 2/HCO 3-) molecular pair is ubiquitous in mammalian
cells and tissues, mainly as a result of oxidative decarboxylation reactions that occur during …
cells and tissues, mainly as a result of oxidative decarboxylation reactions that occur during …
[HTML][HTML] Biodegradable magnesium biomaterials—Road to the clinic
S Amukarimi, M Mozafari - Bioengineering, 2022 - mdpi.com
In recent decades, we have witnessed radical changes in the use of permanent
biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without …
biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without …
Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo
Q Fu, X Yang, M Wang, K Zhu, Y Wang, J Song - ACS nano, 2024 - ACS Publications
Dynamic variations in the concentration and abnormal distribution of endogenous
biomarkers are strongly associated with multiple physiological and pathological states …
biomarkers are strongly associated with multiple physiological and pathological states …
Acid–base balance and cerebrovascular regulation
The regulation and defence of intracellular pH is essential for homeostasis. Indeed,
alterations in cerebrovascular acid–base balance directly affect cerebral blood flow (CBF) …
alterations in cerebrovascular acid–base balance directly affect cerebral blood flow (CBF) …
Fluorinated benzimidazolium salts: Synthesis, characterization, molecular docking studies and inhibitory properties against some metabolic enzymes
Here, a number of symmetric and unsymmetric N-heterocyclic carbene (NHC) precursors
based on benzimidazol-2-ylidene are synthesized. The N-benzyl substituent in these …
based on benzimidazol-2-ylidene are synthesized. The N-benzyl substituent in these …
Development of an Au nanoclusters based activatable nanoprobe for NIR-II fluorescence imaging of gastric acid
M Liang, Q Hu, S Yi, Y Chi, Y Xiao - Biosensors and Bioelectronics, 2023 - Elsevier
Gastric acid is an important functional substance secreted by the stomach of the living
organisms, reflecting the gastric physiological condition. The sensing of gastric acid in vivo …
organisms, reflecting the gastric physiological condition. The sensing of gastric acid in vivo …
[HTML][HTML] Preliminary research on the effect of hyperbaric oxygen therapy in patients with post-COVID-19 syndrome
Negative consequences and medical complications of COVID-19 can persist for up to
several months after initial recovery. These consequences can include stroke, diabetes …
several months after initial recovery. These consequences can include stroke, diabetes …
[HTML][HTML] Tumor associated carbonic anhydrase inhibitors: rational approaches, design strategies, structure activity relationship and mechanistic insights
The emergence of tumor-associated human carbonic anhydrases (hCA) as promising
therapeutic targets has urged rigorous research into the development of potent and selective …
therapeutic targets has urged rigorous research into the development of potent and selective …