In recent decades, the development of targeted drugs has featured prominently in the
treatment of cancer, which is among the major causes of mortality globally. Triazole-fused …

Simple Summary Recently, several studies have shown that acidosis, which is increased
acidity in the blood and other body tissues, is often associated with severe COVID-19. In this …

The carbon dioxide/bicarbonate (CO 2/HCO 3-) molecular pair is ubiquitous in mammalian
cells and tissues, mainly as a result of oxidative decarboxylation reactions that occur during …

In recent decades, we have witnessed radical changes in the use of permanent
biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without …

Dynamic variations in the concentration and abnormal distribution of endogenous
biomarkers are strongly associated with multiple physiological and pathological states …

The regulation and defence of intracellular pH is essential for homeostasis. Indeed,
alterations in cerebrovascular acid–base balance directly affect cerebral blood flow (CBF) …

Here, a number of symmetric and unsymmetric N-heterocyclic carbene (NHC) precursors
based on benzimidazol-2-ylidene are synthesized. The N-benzyl substituent in these …

Gastric acid is an important functional substance secreted by the stomach of the living
organisms, reflecting the gastric physiological condition. The sensing of gastric acid in vivo …

Negative consequences and medical complications of COVID-19 can persist for up to
several months after initial recovery. These consequences can include stroke, diabetes …

The emergence of tumor-associated human carbonic anhydrases (hCA) as promising
therapeutic targets has urged rigorous research into the development of potent and selective …