Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …

A powerful technique for the analysis of nonlinear oscillators is the rigorous reduction to
phase models, with a single variable describing the phase of the oscillation with respect to …

Ventricular arrhythmias have complex causes and mechanisms. Despite extensive
investigation involving many clinical, experimental, and computational studies, effective …

Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a
major cause of death worldwide. Disturbed Na and Ca handling is known to be a major …

This is the second of the two White Papers from the fourth UC Davis Cardiovascular
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …

Calcium/calmodulin-dependent protein kinase II (CaMKII) has emerged as key enzyme in
many cardiac pathologies, especially heart failure (HF), myocardial infarction and …

Early afterdepolarizations (EADs) and delayed afterdepolarizations (DADs) are voltage
oscillations known to cause cardiac arrhythmias. EADs are mainly driven by voltage …

Cardiac alternans refers to a condition in which there is a periodic beat‐to‐beat oscillation in
electrical activity and the strength of cardiac muscle contraction at a constant heart rate …